Brecon, Lampeter, Llandrindod Wells, Llandysul, Newtown and Tregaron are all set to benefit from new Welsh Government investment.
Powys County Council will manage the administration of the programme which includes a package of support including loans, private investment and grants.
The Welsh Government funding is part of the Targeted Regeneration and Investment programme, which is providing £100 million of capital funding across the country over three years to support regeneration projects in town centres and neighbouring areas.
Deputy Housing and Local Government Minister Hannah Blythyn has announced £1.5 million of Welsh Government funding for a new £2.14 million Town Centre Property Investment Fund across Powys and Ceredigion councils. The fund will bring vacant commercial, residential and retail space back into use across the 6 mid Wales towns.
Hannah Blythyn said:
We want to support local businesses, grow our fantastic town centres and create job opportunities in mid Wales. Creating more good quality commercial and retail space will help with this, as will creating homes in the centre of our towns, so people can live and work centrally and contribute to the local economy.
This fund will help to create opportunities out of empty properties and attract more people to our town centres. I look forward to seeing some exciting refurbishments, and businesses growing and prospering across towns in Ceredigion and Powys as a result.